Publikationen Legler

Publikationen Prof. Dr. Daniel Legler

Ruef N, Martínez Magdaleno J, Ficht X, Purvanov V, Palayret M, Wissmann S, Pfenninger P, Stolp B, Thelen F, Barreto de Albuquerque J, Germann P, Sharpe J, Abe J, Legler DF, Stein JV. 2023. Exocrine gland-resident memory CD8+ T cells use mechanosensing for tissue surveillance. Sci Immunol Dec 22;8(90):eadd5724. doi: 10.1126/sciimmunol.add5724. Epub 2023 Dec 22.
Garcia-Seyda N, Song S, Seveau de Noray V, David-Broglio L, Matti C, Artinger M, Dupuy F, Biarnes-Pelicot M, Valignat MP, Legler DF, Bajénoff M, Theodoly O. 2023. Naive T lymphocytes chemotax long distance to CCL21 but not to a source of bioactive S1P. iScience 2023 Aug 19;26(10):107695. doi: 10.1016/j.isci.2023.107695. eCollection 2023 Oct 20.
Melgrati S, Gerken OJ, Artinger M, Radice E, Szpakowska M, Chevigné A, D'Uonnolo G, Antonello P, Thelen S, Pelczar P, Legler DF, Thelen M. 2023. GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity. Front Immunol DOI: 10.3389/fimmu.2023.1242531.
Sigmund EC, Bauer A, Jakobs BD, Tatliadim H, Tacconi C, Thelen M, Legler DF, Halin C. 2023. Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells. PLoS One May 30;18(5):e0285597. doi: 10.1371/journal.pone.0285597. eCollection 2023.
Szpakowska M, D'Uonnolo G, Luís R, Alonso Bartolomé A, Thelen M, Legler DF, Chevigné A. 2023. New pairings and deorphanization among the atypical chemokine receptor family - physiological and clinical relevance. Front Immunol Apr 20;14:1133394. doi: 10.3389/fimmu.2023.1133394. eCollection 2023.
Artinger M, Gerken OJ, Legler DF. 2023. Heparin Specifically Interacts with Basic BBXB Motifs of the Chemokine CCL21 to Define CCR7 Signaling. Int J Mol Sci Jan 14;24(2):1670. doi: 10.3390/ijms24021670.
Rossatti P, Redpath GMI, Ziegler L, Samson GPB, Clamagirand CD, Legler DF, Rossy J. 2022. Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation. BMC Biol Aug 24;20(1):189. doi: 10.1186/s12915-022-01386-0.
Artinger M, Gerken OJ, Purvanov V, Legler DF. 2022. Distinct Fates of Chemokine and Surrogate Molecule Gradients: Consequences for CCR7-Guided Dendritic Cell Migration. Front Immunol 13:913366. doi: 10.3389/fimmu.2022.913366.
Gerken OJ, Artinger M, Legler DF. 2022. Shifting CCR7 towards Its Monomeric Form Augments CCL19 Binding and Uptake. Cells Apr 25;11(9):1444. doi: 10.3390/cells11091444.
Friess MC, Kritikos I, Schineis P, Medina-Sanchez JD, Gkountidi AO, Vallone A, Sigmund EC, Schwitter C, Vranova M, Matti C, Arasa J, Saygili Demir C, Bovay E, Proulx ST, Tomura M, Rot A, Legler DF, Petrova TV, Halin C. 2022. Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics. Cell Rep Feb 1;38(5):110334. doi: 10.1016/j.celrep.2022.110334.
Seumen CHT, Tomasiunaite U, Legler DF, Hauck CR. 2021. Elimination of negative feedback in TLR signalling allows rapid and hypersensitive detection of microbial contaminants. Sci Rep Dec 24;11(1):24414. doi: 10.1038/s41598-021-03618-9.
Patel M, Matti C, Grimsey NL, Legler DF, Javitch JA, Finlay DB, Glass M. 2021. Delineating the interactions between the cannabinoid CB2 receptor and its regulatory effectors; β-arrestins and G protein-coupled receptor kinases. Br J Pharmacol Nov 22. doi: 10.1111/bph.15748. Online ahead of print.
Uetz-von Allmen E, Samson GPB, Purvanov V, Maeda T, Legler DF. 2021. CAL-1 as cellular model system to study CCR7-guided human dendritic cell migration. Front Immunol Sep 16;12:702453. doi: 10.3389/fimmu.2021.702453.
Ghosh S, Feigelson SW, Montresor A, Shimoni E, Roncato F, Legler DF, Laudanna C, Haran G, Alon R. 2021. CCR7 signalosomes are preassembled on tips of lymphocyte microvilli in proximity to LFA-1. Biophys J Aug 17:S0006-3495(21)00680-9. doi: 10.1016/j.bpj.2021.08.014.
Gutjahr JC, Crawford KS, Jensen DR, Naik P, Peterson FC, Samson GPB, Legler DF, Duchene J, Veldkamp CT, Rot A, Volkman BF. 2021. The dimeric form of CXCL12 binds to atypical chemokine receptor 1. Sci Signal Aug 17;14(696):eabc9012. doi: 10.1126/scisignal.abc9012.
Gutjahr JC, Bayer E, Yu X, Laufer JM, Höpner JP, Tesanovic S, Härzschel A, Auer G, Rieß T, Salmhofer A, Szenes E, Haslauer T, Durand-Onayli V, Ramspacher A, Pennisi SP, Artinger M, Zaborsky N, Chigaev A, Aberger F, Neureiter D, Pleyer L, Legler DF, Orian-Rousseau V, Greil R, Hartmann TN. 2021. CD44 Engagement Enhances Acute Myeloid Leukemia Cell Adhesion to the Bone Marrow Microenvironment by Increasing VLA-4 Avidity. Haematologica Aug 1;106(8):2102-2113. doi: 10.3324/haematol.2019.231944.
Artinger M, Matti C, Gerken OJ, Veldkamp CT, Legler DF. 2021. A Versatile Toolkit for Semi-Automated Production of Fluorescent Chemokines to Study CCR7 Expression and Functions. Int J Mol Sci Apr 16;22(8):4158. doi: 10.3390/ijms22084158.
Phan TS, Schink L, Mann J, Merk VM, Zwicky P, Mundt S, Simon D, Kulms D, Abraham S, Legler DF, Noti M, Brunner T. 2021. Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids. Sci Adv Jan 29;7(5):eabe0337. doi: 10.1126/sciadv.abe0337. Print 2021 Jan.
James KD, Legler DF, Purvanov V, Ohigashi I, Takahama Y, Parnell SM, White AJ, Jenkinson WE, Anderson G. 2021. Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus. Blood Adv Jan 12;5(1):99-112. doi: 10.1182/bloodadvances.2020003192.
Kouzeli A, Collins PJ, Metzemaekers M, Meyrath M, Szpakowska M, Artinger M, Struyf S, Proost P, Chevigne A, Legler DF, Eberl M, Moser B. 2020. CXCL14 Preferentially Synergizes With Homeostatic Chemokine Receptor Systems. Front Immunol Oct 5;11:561404. doi: 10.3389/fimmu.2020.561404.
D'Agostino G, Artinger M, Locati M, Perez L, Legler DF, Bianchi ME, Rüegg C, Thelen M, Marchese A, Rocchi MBL, Cecchinato V, Uguccioni M. 2020. β-Arrestin1 and β-Arrestin2 Are Required to Support the Activity of the CXCL12/HMGB1 Heterocomplex on CXCR4. Front Immunol 2020 Sep 18;11:550824. doi: 10.3389/fimmu.2020.550824.
Cosgrove J, Novkovic M, Albrecht S, Pikor NB, Zhou Z, Onder L, Mörbe U, Cupovic J, Miller H, Alden K, Thuery A, O’Toole P, Pinter R, Jarrett S, Taylor E, Venetz D, Heller M, Uguccioni M, Legler DF, Lacey CJ, Coatesworth A, Polak WG, Cupedo T, Manoury B, Thelen M, Stein JV, Wolf M, Leake MC, Timmis J, Ludewig B, Coles MC. 2020. B-cell zone reticular cell microenvironments shape CXCL13 gradient formation. Nat Comm Jul 22;11(1):3677. doi: 10.1038/s41467-020-17135-2.
Matti C, Legler DF. 2020. CCR5 deficiency/CCR5Δ32: resistant to HIV infection at the cost of curtailed CD4+ T cell memory responses. EMBO J Jul 8;e105854. doi: 10.15252/embj.2020105854. Online ahead of print.
Schregle R, Mueller S, Legler DF, Rossy J, Krueger WA, Groettrup M. 2020. FAT10 localizes in dendritic cell aggresome-like induced structures and contributes to their disassembly. J Cell Sci Jun 16:jcs.240085. doi: 10.1242/jcs.240085. Online ahead of print.
Matti C, D'Uonnolo G, Artinger M, Melgrati S, Salnikov A, Thelen S, Purvanov V, Strobel TD, Spannagel L, Thelen M, Legler DF. 2020. CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4. J Leukoc Biol Jun;107(6):1137-1154. doi: 10.1002/JLB.2MA0420-295RRR.
Samson GPB, Legler DF. 2020. Membrane Compartmentalization and Scaffold Proteins in Leukocyte Migration. Front Cell Dev Biol Apr 28;8:285. doi: 10.3389/fcell.2020.00285. eCollection 2020.
Matti C, Salnikov A, Artinger M, D'Agostino G, Kindinger I, Uguccioni M, Thelen M, Legler DF. 2020. ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins. Front Immunol Apr 22;11:720. doi: 10.3389/fimmu.2020.00720. eCollection 2020.
Laufer JM, Hauser MA, Kindinger I, Purvanov V, Pauli A, Legler DF. 2019. Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation. Cell Rep 29(4):995-1009. e6, October 22, 2019.
Ficht X, Ruef N, Stolp B, Samson GPB, Moalli F, Page N, Merkler D, Nichols BJ, Diz-Muñoz A, Legler DF, Niggli V, Stein JV. 2019. In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8+ T Cell-Mediated Host Surveillance. J Immunol 203(9):2377-2387. doi: 10.4049/jimmunol.1900075. Epub 2019 Sep 23.
Jørgensen AS, Larsen O, Uetz-von Allmen E, Lückmann M, Legler DF, Frimurer TM, Veldkamp CT, Hjortø GM, Rosenkilde MM. 2019. Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7. Front Immunol Sep 13;10:2156. doi: 10.3389/fimmu.2019.02156. eCollection 2019.
Jakobs BD, Spannagel L, Purvanov V, Uetz-von Allmen E, Matti C, Legler DF. 2019. Engineering of Nanobodies Recognizing the Human Chemokine Receptor CCR7. Int J Mol Sci Int J Mol Sci. 2019 May 27;20(10). pii: E2597. doi: 10.3390/ijms20102597. Repository
Impellizzieri D, Ridder F, Raeber ME, Egholm C, Woytschak J, Kolios AGA, Legler DF, Boyman O. 2019. IL-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation. J Allergy Clin Immunol 144(1):267-279.
Laufer JM, Kindinger I, Artinger M, Pauli A, Legler DF. 2019. CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70. Front Immunol Jan 14;9:3115. doi: 10.3389/fimmu.2018.03115. eCollection 2018.
Purvanov V, Matti C, Samson GPB, Kindinger I, Legler DF. 2018. Fluorescently Tagged CCL19 and CCL21 to Monitor CCR7 and ACKR4 Functions. Int J Mol Sci Dec 4;19(12). pii: E3876. doi: 10.3390/ijms19123876.
Rossy J, Laufer JM, Legler DF. 2018. Role of Mechanotransduction and Tension in T Cell Function. Front. Immunol. 15 November 2018 | https://doi.org/10.3389/fimmu.2018.02638.
Jørgensen AS, Adogamhe PE, Laufer JM, Legler DF, Veldkamp CT, Rosenkilde MM, Hjortø GM. 2018. CCL19 with CCL21-tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells. J Leukoc Biol Aug;104(2):401-411. doi: 10.1002/JLB.2VMA0118-008R.
Laufer JM, Legler DF. 2018. Beyond migration-Chemokines in lymphocyte priming, differentiation, and modulating effector functions. J Leukoc Biol Apr 18. doi: 10.1002/JLB.2MR1217-494R.
Uetz-von Allmen E, Rippl AV, Farhan H, Legler DF. 2018. A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking. J Leukoc Biol 104(2):375-389. Repository
Laufer JM, Lyck R, Legler DF. 2018. ZAP70 expression enhances chemokine-driven chronic lymphocytic leukemia cell migration and arrest by valency regulation of integrins. FASEB J Mar 28. doi: 10.1096/fj.201701452RR.
Thelen M, Legler DF. 2018. Membrane lipid environment: Potential modulation of chemokine receptor function. Cytokine doi: 10.1016/j.cyto.2018.02.011.
Legler DF, Thelen M. 2018. New insights in chemokine signaling. F1000Res Jan 23;7:95. doi: 10.12688/f1000research.13130.1. eCollection 2018. Review.
Nyffeler J, Chovancova P, Dolde X, Holzer AK, Purvanov V, Kindinger I, Kerins A, Higton D, Silvester S, van Vugt-Lussenburg BMA, Glaab E, van der Burg B, Maclennan R, Legler DF, Leist M. 2018. A structure-activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins. Arch Toxicol 92(3):1225-1247.
Collins PJ, McCully ML, Martínez-Muñoz L, Santiago C, Wheeldon J, Chaucheteux S, Thelen S, Cecchinato V, Laufer JM, Purvanov V, Monneau YR, Lortat-Jacob H, Legler DF, Uguccioni M, Thelen M, Piguet V, Mellado M, Moser B. 2017. Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4. FASEB J 31:3084-3097.
Legler DF, Matti C, Laufer JM, Jakobs BD, Purvanov V, Uetz-von Allmen E, Thelen M. 2017. Modulation of chemokine receptor function by cholesterol: new prospects for pharmacological intervention. Mol Pharmacol 91:331-338.
Legler DF, Thelen M. 2016. Chemokines: chemistry, biochemistry and biological function. Chimia 70:856-859.
Weitzenfeld P, Kossover O, Körner C, Meshel T, Wiemann S, Seliktar D, Legler DF, Ben-Baruch A. 2016. Chemokine axes in breast cancer: factors of the tumor microenvironment re-shape the CCR7-driven metastatic spread of luminal-A breast tumors. J Leuk Biol 99:1009-1025.
Hauser MA, Kindinger I, Laufer JM, Späte A-K, Bucher D, Vanes SL, Krueger WA, Wittmann V, Legler DF. 2016. Distinct CCR7 glycosylation pattern shapes receptor signaling and endocytosis to modulate chemotactic responses. J Leuk Biol 99:993-1007.
Hauser MA, Schaeuble K, Kindinger I, Impellizzieri D, Krueger WA, Hauck CR, Boyman O, Legler DF. 2016. Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration. Immunity Jan 19;44(1):59-72. doi: 10.1016/j.immuni.2015.12.010.
Hauser MA, Legler DF. 2016. Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes. J Leukoc Biol 99:869-892.
Herrmann VL, Wieland DE, Legler DF, Wittmann V, Groettrup M. 2016. The STEAP1262-270 peptide encapsulated into PLGA microspheres elicits strong cytotoxic T cell immunity in HLA-A*0201 transgenic mice-a new approach to immunotherapy against prostate carcinoma. Prostate 75:456-468.
Schachtner H, Weimershaus M, Stache V, Plewa N, Legler DF, Höpken UE, Maritzen T. 2015. Loss of Gadkin Affects Dendritic Cell Migration In Vitro. PLoS One Dec 1;10(12):e0143883. doi: 10.1371/journal.pone.0143883. eCollection 2015.
Ackerknecht M, Hauser MA, Legler DF, Stein JV. 2015. In vivo TCR Signaling in CD4(+) T Cells Imprints a Cell-Intrinsic, Transient Low-Motility Pattern Independent of Chemokine Receptor Expression Levels, or Microtubular Network, Integrin, and Protein Kinase C Activity. Front Immunol Jun 8;6:297. doi: 10.3389/fimmu.2015.00297. eCollection 2015.
Baschieri F, Uetz-von Allmen E, Legler DF, Farhan H. 2015. Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity. Cell Cycle 14:1139-1147.
Wu X, Wu J, Li H, Legler DF, Marshall AJ, Lin F. 2015. Analysis of CCR7 mediated T cell transfectant migration using a microfluidic gradient generator. J Immunol Methods 419:9-17.
Maritzen T, Schachtner H, Legler DF. 2015. On the move: Endocytic trafficking in cell migration. Cell Mol Life Sci 72(11):2119-2134.
Tillmann KD, Reiterer V, Baschieri F, Hoffmann J, Millarte V, Hauser MA, Mazza A, Atias N, Legler DF, Sharan R, Weiss M, Farhan H. 2015. Regulation of Sec16 levels and dynamics links proliferation and secretion. J Cell Sci 128(4):670-682.
Legler DF, Uetz-von Allmen E, Hauser MA. 2014. CCR7: Roles in cancer cell dissemination, migration and metastasis formation. Int J Biochem Cell Biol 54:78-82.
Weber M, Hauschild R, Schwarz J, Moussion C, de Vries I, Legler DF, Luther SA, Bollenbach T, Sixt M. 2013. Interstitial dendritic cell guidance by haptotactic chemokine gradients.Science 339(6117):328-32.
Bruckner M, Dickel D, Singer E, Legler DF. 2012. Converse regulation of CCR7-driven human dendritic cell migration by prostaglandin E2 and liver X receptor activation.Eur J Immunol 42(11):2949-2958.
Schaeuble K, Hauser MA, Rippl AV, Bruderer R, Otero C, Groettrup M, Legler DF. 2012. Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration.J Cell Sci 125(19):4463-4474.
Bruckner M, Dickel D, Singer E, Legler DF. 2012. Distinct modulation of chemokine expression pattern in human monocyte-derived dendritic cells by prostaglandin E2.Cell Immunol 276:52-58.
Schaeuble K, Hauser MA, Singer E, Groettrup M, Legler DF. 2011. Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration. J Immunol 187(11):5645-52.
Johannsen A, Genolet R, Legler DF, Luther SA, Luescher IF. 2010. Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgenic mice. J Immunol 185:3445-3455.
Metzner C, Legler DF, Dangerfield JA. 2010. Surface engineering of biomembranes with glycosylphosphatidylinositol-anchored proteins and its applications. In GPI membrane anchors-the much needed link. Ed Dangerfield JA, Metzner C. Bentham e-book Chapter 6: 83-97. eISBN: 978-1-60805-123-6, 2010
Schumann K, Lämmermann T, Bruckner M, Legler DF, Polleux J, Spatz JP, Schuler G, Förster R, Lutz MB, Sorokin L, Sixt M. 2010. Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells. Immunity 32(5):703-713.
Legler DF, Bruckner M, Uetz-von Allmen E, Krause P. 2010. Prostaglandin E(2) at new glance: Novel insights in functional diversity offer therapeutic chances. Int J Biochem Cell Biol 42(2):198-201.
Boneberg EM, Illges H, Legler DF, Fürstenberger G. 2009. Soluble CD146 is generated by ectodomain shedding of membrane CD146 in a calcium-induced, matrix metalloprotease-dependent process. Microvasc Res 78(3):325-31.
Boneberg EM, Legler DF, Hoefer MM, Ohlschlegel C, Steininger H, Füzesi L, Beer GM, Dupont-Lampert V, Otto F, Senn HJ, Fürstenberger G. 2009. Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer. Br J Cancer 101(4):605-614.
Krause P, Bruckner M, Uermosi C, Singer E, Groettrup M, Legler DF. 2009. Prostaglandin E(2) enhances T cell proliferation by inducing the co-stimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells. Blood 113(11):2451-2460.
Otero C, Eisele PS, Schaeuble K, Groettrup M, Legler DF. 2008. Distinct motifs of the chemokine receptor CCR7 regulate signal transduction, receptor trafficking, and chemotaxis. J Cell Sci 121:2759-2767.
Boneberg EM, Legler DF, Senn HJ, Fürstenberger G. 2008. Reduced expression of cyclooxygenase-2 in primary breast cancer. J Natl Cancer Inst 100:1042-1043.
Segura JM, Guillaume P, Mark S, Dojcinovic D, Johannsen A, Bosshard G, Angelov G, Legler DF, Vogel H, Luescher IF. 2008. Increased mobility of major histocompatibility complex I-peptide complexes decreases the sensitivity of antigen recognition. J Biol Chem 283:24254-24263.
Lukasiak S, Schiller C, Oehlschlaeger P, Schmidtke G, Krause P, Legler DF, Autschbach F, Schirmacher P, Breuhahn K, Groettrup M. 2008. Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon. Oncogene 27:6068-6074.
Uetz-von Allmen E, Koch M, Fritz G, Legler DF. 2008. V domain of RAGE interacts with AGEs on prostate carcinoma cells. Prostate 68:748-758.
Krause P, Singer E, Darley PI, Klebensberger J, Groettrup M, Legler DF. 2007. Prostaglandin E2 is a key factor for monocyte-derived dendritic cell maturation: enhanced T cell stimulatory capacity despite IDO. J Leuk Biol 82(5):1106-1114.
Schlosser E, Otero C, Wünsch C, Kessler BM, Edelmann M, Brunisholz R, Drexler I, Legler DF*, Groettrup M*. 2007. A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins. EMBO Rep 8:945-951. * share senior authorship
Otero C, Groettrup M, Legler DF. 2006. Opposite fate of endocytosed CCR7 and its ligands: recycling versus degradation. J Immunol 177:2314-2323.
Langhorst MF, Reuter A, Luxenhofer G, Boneberg EM, Legler DF, Plattner H, Stuermer CAO. 2006. Preformed reggie/flotillin caps: stable priming platforms for macrodomain assembly in T cells. FASEB J 20:711-713, and FASEB J express article online
Nachbur U, Kassahn D, Yousefi S, Legler DF, Brunner T. 2006. Posttranscriptional regulation of Fas (CD95) ligand activity by lipid rafts. Blood 107:2790-2796.
Legler DF, Krause P, Scandella E, Singer E, Groettrup M. 2006. Prostaglandin E2 is generally required for human dendritic cell migration and exerts its effect via EP2 and EP4 receptors. J Immunol 176:966-973.
Legler DF, Doucey MA, Schneider P, Chapatte L, Bender FC, Bron C. 2005. Differential insertion of GPI-anchored GFPs into lipid rafts of live cells. FASEB J 19:1-3, and FASEB J express article online
Stuermer CAO, Langhorst MF, Wiechers M, Legler DF, Hannbeck S, Guse AH, Plattner H. 2004. PrP^c capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction. FASEB J 18:1731-1733, and FASEB J express article online
Legler DF, Johnson-Leger C, Wiedle G, Bron C, Imhof BA. 2004. The αvβ3 integrin as a tumor homing ligand for lymphocytes. EurJ Immunol 34:1608-1616.
Scandella E, Men Y, Legler DF, Gillessen S, Prikler L, Ludewig B, Groettrup, M. 2004. CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2. Blood 103:1595-1601.
Doucey MA, Legler DF, Faroudi M, Boucheron N, Baumgartner P, Naeher D, Cebecauer M, Hudrisier D, Ruegg C, Palmer E, Valitutti S, Bron C, Luescher IF. 2003. The β1 and β3 integrins promote T cell receptor-mediated cytotoxic T lymphocyte activation. J Biol Chem 278:26983-26991.
Legler DF, Micheau O, Doucey MA, Tschopp J, Bron C. 2003. Recruitment of TNF receptor 1 to lipid rafts is essential for TNFα-mediated NF-κB activation. Immunity 18:655-664.
Guillaume P, Legler DF, Boucheron N, Doucey MA, Cerottini JC, Luescher IF. 2003. Soluble major histocompatibility complex-peptide octamers with impaired CD8 binding selectively induce Fas-dependent apoptosis. J Biol Chem 278:4500-4509.
Gaide O, Favier B, Legler DF, Bonnet D, Brissoni B, Valitutti S, Bron C, Tschopp J, Thome M. 2002. Carma1 is a critical lipid raft-associated regulator of TCR-induced NF-κB activation. Nat Immunol 3:836-843.
Rothenberger S, Rousseaux M, Knecht H, Bender FC, Legler DF, Bron C. 2002. Association of the Epstein-Barr virus Latent membrane protein 1 with lipid rafts is mediated through its N-terminal region. Cell Mol Life Sci 59:171-180.
Legler DF, Doucey MA, Cerottini JC, Bron C, Luescher IF. 2001. Selective inhibition of CTL activation by a dipalmitoyl-phospholipid that prevents the recruitment of signaling molecules to lipid rafts. FASEB J 15:1601-1603, and FASEB J express article online
Doucey MA, Legler DF, Boucheron N, Cerottini JC, Bron C, Luescher IF. 2001. CTL activation is induced by cross-linking of TCR/MHC-peptide - CD8/p56^Lck adducts in rafts. Eur J Immunol 31:1561-1570.
Legler DF, Wiedle G, Ross FP, Imhof BA. 2001. Superactivation of integrin αvβ3 by low agonist concentrations. J Cell Sci 114:1545-1553.
Wehrli N, Legler DF, Finke D, Toellner KM, Loetscher P, Baggiolini M, Mac-Lennan ICM, Acha-Orbea H. 2001. Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes. Eur J Immunol 31:609-616.
Brandes M, Legler DF, Spoerri B, Schaerli P, Moser B. 2000. Activation-dependent modulation of B lymphocyte migration to chemokines. Int Immunol 12:1285-1292.
Arenzana-Seisdedos F, Amara A, Thomas D, Virelizier JL, Baleux F, Clark-Lewis I, Legler DF, Moser B, Baggiolini M. 1998. β-chemokine MDC and HIV-1 infection. Science 281:487a.
Willimann K*, Legler DF*, Loetscher M, Stuber Roos R, Delgado MB, Clark-Lewis I, Baggiolini M, Moser B. 1998. The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7. Eur J Immunol 28:2025-2034. * are both considered as first authors
Legler DF, Loetscher M, Stuber Roos R, Clark-Lewis I, Baggiolini M, Moser B. 1998. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med 187:655-660.
Loetscher M, Amara A, Oberlin E, Brass N, Legler DF, Loetscher P, D'Apuzzo M, Meese E, Rousset D, Virelizier JL, Baggiolini M, Arenzana-Seisdedos F, Moser B. 1997. TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function. Curr Biol 7:652-660.
Stuber Roos R, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B. 1997. Identification of CCR8, the receptor for the human CC chemokine I-309. J Biol Chem 272:17251-17254.
Oberlin E, Amara A, Bachelerie F, Bessia C, Virelizier JL, Arenzana-Seisdedos F, Schwartz O, Heard JM, Clark-Lewis I, Legler DF, Loetscher M, Baggiolini M, Moser B. 1996. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382:833-835.
Legler DF, Loetscher M, Jones SA, Dahinden CA, Arock M, Moser B. 1996. Expression of high- and low-affinity receptors for C3a on the human mast cell line, HMC-1. Eur J Immunol 26:753-758.